627 UVB-generated microvesicle particles mediate systemic immunosuppression
نویسندگان
چکیده
منابع مشابه
UVB Generates Microvesicle Particles via Platelet-activating Factor-receptor Signaling: A Novel Pathway by which a Skin-specific Stimulus Exerts Systemic Effects
BACKGROUND MATERIALS & METHODS RESULTS RESULTS Cont’d 1. UVB generates MVP in vitro in a process involving PAF-R signaling. 2. UVB also generates MVP in human skin. 3. As MVP are thought to be functional signaling agents, these studies could provide a mechanism whereby UVB can generate systemic effects. SUMMARY For in vitro experiments, the human keratinocyte-derived cell line HaCaT was used. H...
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Ubiquitous pro-oxidative stressor ultraviolet B radiation (UVB) to human or mouse skin generates platelet-activating factor (PAF) and novel oxidatively modified glycerophosphocholines (Ox-GPCs) with PAF-receptor (PAF-R) agonistic activity. These lipids mediate systemic immunosuppression in a process involving IL-10. The current studies sought to determine the functional significance of UVB-medi...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2020
ISSN: 0022-202X
DOI: 10.1016/j.jid.2020.03.638